Single-copy chromosomal integration systems for Francisella tularensis

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Single-copy chromosomal integration systems for Francisella tularensis.

Francisella tularensis is a fastidious Gram-negative bacterium responsible for the zoonotic disease tularemia. Investigation of the biology and molecular pathogenesis of F. tularensis has been limited by the difficulties in manipulating such a highly pathogenic organism and by a lack of genetic tools. However, recent advances have substantially improved the ability of researchers to genetically...

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F rancisella tularensis was first isolated in 1912 from rodents suffering from a plague-like disease in Tulare County, Calif. Subsequently, investigators learned that this small, gram-negative bacterium infects many animal species and is associated with a wide range of diseases. In humans, the bacterium causes a serious, sometimes fatal disease, called tularemia, which is also known as rabbit f...

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Etymologia: Francisella tularensis

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1. Outbreak of pneumonic plague in village Hatkoti, District Shimla, Himachal Pradesh, India, February 2002. New Delhi (India): Directorate General of Health Services, Ministry of Health and Family Welfare; April 30, 2002. 2. Dennis DT, Gage KL, Gratz N, Poland JD, Tikhomirov E. Plague manual: epidemiology, distribution, surveillance and control. Geneva: World Health Organization; (WHO/CDS/CSR/...

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ژورنال

عنوان ژورنال: Microbiology

سال: 2009

ISSN: 1350-0872,1465-2080

DOI: 10.1099/mic.0.022491-0